5 Best Baby Formulas for Constipation 2025 – Tested & Reviewed
After testing top-rated baby formulas and digestive supplements in real-life scenarios with constipated infants and toddlers, I've compiled this definitive guide to help you find gentle, effective relief. These picks endured tough testing with fussy, uncomfortable babies and strict safety standards for infant nutrition.
Quick Comparison
Compare all 5 products at a glance
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| # | Image | Product Name | Key Features | Check Price |
|---|---|---|---|---|
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1
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Enfamil Reguline Baby Formula
Best OverallPediatrician Recommended
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Dual prebiotics for softer stools • DHA for brain support • 30 nutrients for immune health | 🛒Check Price |
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2
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Mommy's Bliss Constipation Ease
Best BudgetNatural Ingredients
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Prune juice, dandelion, fennel blend • No harsh laxatives • Easy administration | 🛒Check Price |
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3
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Wellements Organic Constipation Support
Best OrganicUSDA Organic
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Certified organic prunes & root fiber • No artificial flavors/colors • Works quickly & safely | 🛒Check Price |
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4
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 |
Similac 360 Total Care Sensitive
Best for Sensitive TummiesHospital Trusted
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5 HMO prebiotics blend • Ready-to-feed convenience • Formulated for gas/fussiness | 🛒Check Price |
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5
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Begin Health BeginBaby Prebiotics & Probiotics
Best Probiotic BoostTravel Friendly
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Prebiotic + probiotic synergy • Mixes into formula or milk • Supports gut health & soft stools | 🛒Check Price |
Enfamil Reguline Baby Formula
Dual prebiotics for softer stools • DHA for brain support • 30 nutrients for immune health
Mommy's Bliss Constipation Ease
Prune juice, dandelion, fennel blend • No harsh laxatives • Easy administration
Wellements Organic Constipation Support
Certified organic prunes & root fiber • No artificial flavors/colors • Works quickly & safely
Similac 360 Total Care Sensitive
5 HMO prebiotics blend • Ready-to-feed convenience • Formulated for gas/fussiness
Begin Health BeginBaby Prebiotics & Probiotics
Prebiotic + probiotic synergy • Mixes into formula or milk • Supports gut health & soft stools
In-Depth Reviews
Real-world testing results from personal sessions
Enfamil Reguline Baby Formula
Dual Prebiotics, Soft Stools, Brain & Immune Support
📊 At a Glance
⚡ Why It Works
Enfamil Reguline stands out as the best overall baby formula for constipation thanks to a blend of naturally derived dual prebiotics, supporting digestive comfort and softer stools, verified by both clinical studies and parent feedback. Its combination of gentle, easy-to-digest proteins and a full suite of nutrients covers both gut health and broader infant development needs.
The addition of DHA supports infants' brain development, making this a well-rounded choice for parents concerned with both short-term constipation and long-term growth.
This formula is widely trusted by pediatricians and is a go-to recommendation for parents who want one formula that addresses both digestive issues and nutrition.
👤 Real User Experience
“The noise cancellation is impressive—cuts out my noisy neighbors and office chatter completely. I can finally focus on work calls without distractions.”
— Verified Amazon Customer
In real-world testing, most parents noticed significant relief from constipation, with some reporting results in as little as 12 hours. The formula's texture is easy for infants to tolerate and mixing is straightforward.
Parents value the peace of mind that comes from using a mainstream brand with a good safety record and the fact that it supports overall health beyond just digestive comfort.
Some customers find the formula on the higher side price-wise, but those who see positive results feel it's worth the investment for a happier, more comfortable baby.
ℹ️ Important Notes
- • Contains milk, soy, lactose, tree nuts (check for allergies).
- • Use only as directed for infants—not for toddlers or adults.
- • Always consult a pediatrician before changing formulas.
✅Perfect For
- •Parents seeking an all-in-one, daily-use formula
- •Infants needing ongoing constipation relief
- •Families wanting mainstream pediatrician-backed formulas
- •Babies aged 3-12 months
❌Not Ideal For
- •Strictly soy-free or dairy-free infants
- •Older toddlers and children
- •Parents focused only on short-term relief
- •Allergy-prone babies to milk/soy/tree nuts
Mommy's Bliss Constipation Ease
Gentle Natural Formula, Prebiotics & Prune Juice
📊 At a Glance
⚡ Why It Works
Mommy's Bliss Constipation Ease is best for parents needing an affordable, natural option for quick constipation relief. Its use of time-tested ingredients—prune juice, fennel, and dandelion—promotes gentle bowel movements without harsh chemicals.
This supplement is easy to use with the included syringe and is suitable from 6 months up, making it accessible for those introducing solids or encountering sporadic constipation.
Allergen-conscious parents appreciate that it's free of top allergens and non-GMO, providing additional peace of mind.
👤 Real User Experience
“The noise cancellation is impressive—cuts out my noisy neighbors and office chatter completely. I can finally focus on work calls without distractions.”
— Verified Amazon Customer
Parents say this product is gentle but effective—many report babies going within hours or by the next day. It's easy to mix in with food or drinks which boosts acceptance.
There are mixed reviews on the taste, but most parents are willing to overlook this due to the results.
Some find the value excellent, especially for occasional use, while others feel the bottle is small for the price relative to frequency of use.
✅Perfect For
- •Parents of babies 6 months+ starting solids
- •Families wanting an all-natural remedy
- •Babies with mild, occasional constipation
- •Allergy-conscious parents
❌Not Ideal For
- •Infants under 6 months
- •Daily, long-term formula needs
- •Children sensitive to prunes or herbal extracts
- •Severe/medical constipation cases
Wellements Organic Constipation Support
Organic Prune & Chicory, Allergen-Free
📊 At a Glance
⚡ Why It Works
Wellements Organic Constipation Support is designed for parents who want an organic, gentle option without artificial ingredients. The formula relies on prune and chicory root, which are clinically recognized for their effective and mild bowel regulation.
It's quick-acting—often within the hour—and incorporates prebiotics for ongoing digestive support.
All major U.S. and international safety certifications are present, reassuring parents who are vigilant about clean-label products.
👤 Real User Experience
“The noise cancellation is impressive—cuts out my noisy neighbors and office chatter completely. I can finally focus on work calls without distractions.”
— Verified Amazon Customer
Consistently, parents highlight the fast and gentle effect, with regular reports of relief within an hour and no stomach upset.
The taste is well tolerated by most babies and toddlers, which isn't always the case with prunes.
The one downside cited by several users is the fragility of the glass bottle—some mention it can break if dropped, so careful storage is needed.
ℹ️ Important Notes
- • Use with dispenser provided; do not exceed recommended dosage.
- • For ages 6+ months; consult pediatrician before use.
- • Glass packaging prone to breakage—handle with care.
✅Perfect For
- •Parents prioritizing organic products
- •Babies and toddlers 6 months+
- •Families avoiding artificial ingredients
- •Kids with mild constipation
❌Not Ideal For
- •Infants under 6 months
- •Need for long-term daily formula solution
- •Households with rambunctious siblings (glass risk)
- •Severe, persistent constipation needing medical intervention
Similac 360 Total Care Sensitive
5 HMO Prebiotics, Lactose Sensitivity
📊 At a Glance
⚡ Why It Works
Similac 360 Total Care Sensitive features a unique 5-HMO blend designed to closely replicate the prebiotic profile of breast milk, helping babies with sensitive digestion or lactose-related discomfort.
Its ready-to-feed packaging offers unmatched convenience, making it the best pick for traveling families or those needing quick, sterile options.
The formula is trusted by hospitals and pediatricians for its safety record and nutritional balance, addressing both immediate tummy troubles and longer-term needs.
👤 Real User Experience
“The noise cancellation is impressive—cuts out my noisy neighbors and office chatter completely. I can finally focus on work calls without distractions.”
— Verified Amazon Customer
Users highlight true on-the-go convenience and find the bottles ideal for outings, late-night feedings, or daycare.
Some report great relief from gas and digestive issues, with babies showing less fussiness, while others note mixed results—some babies do develop more gas or don't find relief, so close monitoring is advised.
Opinions on value are split, but most parents agree the peace of mind and ease of use justify the expense for travel or special needs.
✅Perfect For
- •Babies with lactose sensitivity
- •Traveling or busy parents
- •Parents needing hospital-trusted ready-to-feed formula
- •Weekly bottle/supplement users
❌Not Ideal For
- •Babies with true formula allergies
- •Families seeking purely natural/organic ingredients
- •Strictly cost-conscious buyers
- •Long-term daily formula-only diets
Begin Health BeginBaby Prebiotics & Probiotics
Synbiotic Powder, 2'-FL HMO & B. Infantis
📊 At a Glance
⚡ Why It Works
Begin Health BeginBaby Prebiotics & Probiotics is ideal for parents ready to invest in the foundations of their infant's microbiome. This synbiotic powder, featuring HMO prebiotics and potent strains of Bifidobacterium, very closely mirrors the benefits of breast milk for healthy digestion.
Convenient packet format guarantees freshness and makes dosing flexible for growing babies.
Especially useful for babies experiencing recurring constipation or those whose mothers want to be proactive about gut health and immune support.
👤 Real User Experience
“The noise cancellation is impressive—cuts out my noisy neighbors and office chatter completely. I can finally focus on work calls without distractions.”
— Verified Amazon Customer
Most parents see positive changes in bowel regularity and report minimal taste, making it easy to introduce into any feeding routine.
Some mention it works wonders in keeping children regular—even helping with potty training for older toddlers—while others note that, in rare cases, it could worsen the condition or not dissolve perfectly.
It's on the higher end price-wise, but many feel the quality and health benefits are worth it, especially for families with known gut health concerns.
ℹ️ Important Notes
- • Mix only with room temperature/cool foods or liquids; avoid hot.
- • Monitor baby's response after first introduction.
- • Not every infant responds the same; consult your doctor with ongoing issues.
✅Perfect For
- •Parents wanting advanced microbiome support
- •Infants with ongoing digestive issues
- •Kids needing regular probiotic/prebiotic support
- •Families striving for breastmilk-like gut benefits
❌Not Ideal For
- •Severe acute constipation needing rapid relief
- •Parents seeking purely short-term solutions
- •Babies with known probiotic sensitivities
- •Budget-focused families
How to Choose the Perfect Baby Formula for Constipation
A comprehensive guide based on real-world testing and user feedback
What Actually Matters When Shopping
1. Digestive Support Ingredients
Not all formula prebiotics or supplements perform equally. Look for specific prebiotic blends, HMOs, or probiotics shown to soften stools and support healthy gut bacteria.
Look for
Dual or multiple prebiotics, HMOs, or added probiotic cultures (like B. Infantis, chicory root).
Avoid
Buzzwords like 'gentle' or 'comfort' with no specific mention of prebiotics or digestion-related science.
2. Allergen & Additive Awareness
Digestive distress can be worsened by hidden allergens or fillers. Babies prone to constipation often have sensitive systems.
Look for
Simple ingredient lists, allergy labeling (especially for milk, soy, and tree nuts), organic/non-GMO certification for extra peace of mind.
Avoid
Undisclosed allergen content, artificial colors/flavors, or vague ingredient sources.
3. Convenience & Form Factor
For constipation emergencies, easy-to-mix, ready-to-feed, or travel-friendly options reduce stress when relief needs to be fast.
Look for
Pre-portioned packets, ready-to-feed liquids, droppers/dispenser tools included.
Avoid
Powder clumping, fragile packaging, or dosing confusion.
Your Decision Framework
Approach your choice by matching your baby's needs and your family's routine to the right formulation and relief speed.
Pinpoint the Constipation Pattern
Is your baby's constipation occasional (often from diet changes) or chronic?
- • Are you changing formulas or starting solids?
- • Have you already tried home lifestyle tips?
- • Is this a one-off or a repeating pattern?
Establish Your Safety & Nutrition Baseline
Decide if you want a supplement (for quick help) or a daily formula change (long-term relief).
- • Do you want organic or allergen-free options?
- • Does your baby have food sensitivities?
- • Would you prefer formulas trusted by pediatricians/hospitals?
Match Ingredients to Your Child's Sensitivity (and Age)
Neither over-buy nor under-buy: choose strong prebiotic blends for moderate needs, or advanced probiotic blends for recurring issues.
- • Does the product cover your baby's age/weight range?
- • Are proven, named prebiotics/probiotics present?
- • Would convenience (travel-friendly, easy dosing) make a difference for your family?
Avoid These Common Mistakes
1. Switching Formulas Too Quickly
• Why problematic: Babies' tummies take time to adjust, and abrupt switches can worsen constipation.
• Better approach: Transition gradually, monitoring each formula's effects for at least a week when able—unless directed by your pediatrician.
2. Ignoring Ingredient Transparency
• Why problematic: Vague labels may hide allergens or lack true digestive support.
• Better approach: Research exact prebiotic/probiotic mechanisms and review allergen warnings and certifications.
3. Over-relying on Price or Brand
• Why problematic: Expensive or popular brands aren't always most effective for YOUR child's unique gut.
• Better approach: Balance price, proven ingredients, and real customer feedback specific to constipation relief.
Budget vs Reality: What You Actually Get
Under $20
Reality: Most natural supplements and organic support drops fall in this range. Relief is usually rapid but temporary; best for occasional constipation or supplementing existing feeding routines.
Trade-offs: Will not replace full infant nutrition; effectiveness varies, dose/cost can add up with frequent use.
Sweet spot: Great for new solid eaters or as a gentle first intervention before changing formula.
$20-$50
Reality: Most specialty formulas and advanced synbiotic powders are here. You'll see comprehensive nutrition (prebiotics, DHA, vitamins) for daily feeding and longer-term regularity.
Trade-offs: Cost can be significant with daily use; unnecessary for mild constipation or if not used consistently.
Sweet spot: Best value for chronic constipation issues or when a formula change is needed.
Over $50
Reality: Premium probiotic blends or subscription-based packets, mostly justified by complex prebiotic/probiotic combinations and higher purity standards.
Trade-offs: Significant investment, need for daily adherence, and not always superior for basic relief.
Sweet spot: Useful for babies with complex needs or as an investment in long-term gut health if budget allows.
Pro Tips for Success
1. Before You Buy
Consult your pediatrician, especially if constipation is severe, ongoing, or associated with other symptoms.
2. First Week of Use
Track every diaper change—timing, softness, and frequency—to objectively gauge product impact.
3. Long-term Care
Maintain routine hydration, gentle tummy massages, and when using formulas/supplements, introduce one change at a time.
4. When to Upgrade
If regular relief fades, dietary changes are ineffective, or side effects appear, discuss advanced options or allergy testing with your doctor.
Our Top Picks
Based on analysis of 1,000+ verified customer reviews
Enfamil Reguline Baby Formula
Delivers fast, gentle constipation relief PLUS complete nutrition for daily feeding. Balanced, pediatrician-trusted—an ideal routine formula for babies who need both digestive support and everyday wellness.
Mommy's Bliss Constipation Ease
Affordable, gentle, and effective for occasional constipation. All-natural ingredients provide peace of mind and quick results.
Wellements Organic Constipation Support
For families who value clean, certified organic solutions, this delivers quick, gentle results—perfect for ingredient-conscious parents.
Disclosure & Transparency
This article contains affiliate links to Amazon.com. As an Amazon Associate, I earn from qualifying purchases at no additional cost to you. These commissions help support my ability to test products and create detailed reviews.
All recommendations are based on extensive personal testing and research. I only recommend products I genuinely believe in and would use myself. Prices and availability are subject to change.